Mg Block of Drosophila NMDA Receptors Is Required for Long-Term Memory Formation and CREB-Dependent Gene Expression
نویسندگان
چکیده
Tomoyuki Miyashita,1 Yoshiaki Oda,2 Junjiro Horiuchi,3 Jerry C.P. Yin,4 Takako Morimoto,2 and Minoru Saitoe1,* 1Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo 156-8502, Japan 2Laboratory of Cellular Neurobiology, School of Science, Tokyo University of Pharmacy and Lifesciences, Hachioji, Tokyo 192-0392, Japan 3Center for Priority Areas, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397, Japan 4Departments of Genetics and Psychiatry, University of Wisconsin at Madison, Madison, WI 53706-3434, USA *Correspondence: [email protected] DOI 10.1016/j.neuron.2012.03.039
منابع مشابه
Mg2+ Block of Drosophila NMDA Receptors Is Required for Long-Term Memory Formation and CREB-Dependent Gene Expression
NMDA receptor (NMDAR) channels allow Ca(2+) influx only during correlated activation of both pre- and postsynaptic cells; a Mg(2+) block mechanism suppresses NMDAR activity when the postsynaptic cell is inactive. Although the importance of NMDARs in associative learning and long-term memory (LTM) formation has been demonstrated, the role of Mg(2+) block in these processes remains unclear. Using...
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